7-Day Colombia Itinerary: Medellin, Guatape & Cartagena (2026)

Only have a week? This 7-day Colombia itinerary combines the country's two most loved destinations - Medellin and Cartagena - plus the iconic day trip to Guatape. It is the perfect plan for first-time visitors who want culture, color, nature and Caribbean beaches without rushing.

Day 1 - Arrive in Medellin

Land in Medellin, the City of Eternal Spring. Settle into El Poblado or Laureles, grab a Colombian coffee and take an easy evening walk around Provenza. Rest up for a big week.

Day 2 - Comuna 13 and city highlights

Spend the morning on the famous Comuna 13 tour: street art, outdoor escalators and an inspiring story of transformation, best experienced with a local guide. In the afternoon, ride the metrocable for sweeping city views.

Day 3 - Day trip to Guatape and El Penol

Take a day trip to Guatape: climb the 740 steps of La Piedra del Penol for one of Colombia's best views, then wander the colorful streets and lakeside town. Head back to Medellin for a final paisa dinner.

Day 4 - Fly to Cartagena

Catch a short morning flight to Cartagena de Indias on the Caribbean coast. Check in near the Walled City and spend the afternoon getting lost in colorful colonial streets, plazas and sunset views from the city walls.

Day 5 - Cartagena Walled City and San Felipe

Explore the historic Walled City, the Castillo San Felipe and the Getsemani neighborhood with a local guide who brings the history to life. Enjoy the Caribbean nightlife in the evening.

Day 6 - Rosario Islands

Escape to the Rosario Islands for turquoise water, snorkeling and beach time - an easy boat trip from Cartagena and a highlight of any Colombia trip.

Day 7 - Last morning and departure

Pick up souvenirs, enjoy fresh fruit and a final Caribbean breakfast before heading to the airport.

Transport and tips

• Flights: Medellin to Cartagena takes about 1 hour and is affordable if booked ahead.
• Pace: This plan is relaxed; add 2-3 days for the Coffee Region (Eje Cafetero) if you can.
• Money: Carry some cash and agree on taxi and tour prices in advance.

Make it yours with local guides

The best version of this itinerary is one guided by locals. On GuiME you book directly with certified local guides in Medellin, Guatape, Cartagena and beyond - authentic experiences, clear prices and no middlemen. Build your perfect week and travel Colombia like a local.